FOXBORO — Bills safety Donte Whitner is sick of living life as a punchline.

Whitner is 0-8 in his career against the Patriots, and told Buffalo-area reporters this week New England players end up laughing at the Bills “every time we play New England.”

“We want to get things turned around, but at the same time it’s football teams with grown men laughing at other grown men on the football field,” he said after he alleged the Packers were chuckling at them in the waning moments of Buffalo’s 34-7 loss last week to Green Bay.

“That happened to us in the ballgame last week, and it happens every time we play New England.”

The last time Buffalo defeated New England was on Sept. 7, 2003, a 31-0 curb stomping of epic proportions that featured Lawyer Milloy and Drew Bledsoe whipping up on their former team, and the unlikely sight of Buffalo’s 350-pound defensive tackle Sam Adams returning an interception 37 yards for a touchdown.

Since that sunny and surreal day in upstate New York, the Patriots have done a lot of laughing at the expense of the Bills. They’ve posted 11 straight wins over the weak sisters of the AFC East, and in that time, have outscored Buffalo 330-120 — an average score of 33-11.

While the last two games have been decided by a total of eight points, seven of the wins over Buffalo have been by 10 points or more, and four of them have been by 28 or more points, including wins of 38-7 and 56-10 over the Bills in 2007.

“Yeah, by the end of the fourth quarter they’re laughing at us,” said Whitner of the Pats after last year’s Monday Night loss to New England. ”It always happens.”

If, as Whitner suggests, the Patriots have been laughing at Buffalo, it’s because quarterback Tom Brady has done more than his share of making the Bills the butt of the joke. Going all the way back to 2001, Brady is 15-1 against the Bills — those 15 wins represents the highest regular-season victory total he has against any opponent. In those 16 games, he has 33 touchdown passes, a 65 percent completion percentage and 3,713 passing yards against the Bills,

Brady was asked this week about the improbable run of success he has enjoyed at the expense of the Bills, and ever the diplomat, he delicately replied that their success against the Bills has been because Buffalo has been “in transition.”

Since September 2003. That’s a looooong transition.

“Yeah, we have [been successful],” Brady acknowledged. “They have a lot of good players. There’s no doubt about that. They have guys that really play hard. We really had our hands full with them last year and they’re playing really hard this year.

“Really, whatever happened in the past, it doesn’t have much bearing on what’s going to happen this week because they have different coaches, they have a different scheme. We’ve really never played this defensive coordinator before. So, I think as an offense, we’re trying to — as we always do — figure out what they’re doing and what they do well.

“We expect a tough game as always. Hopefully, we come out ahead.”

In a league where parity is a fundamental truth, how does one team dominate the other so consistently over such an extended stretch? To Brady’s point, there has been little consistency in upstate New York: Since the 2003 opener — when head coach Gregg Williams and Bledsoe led Buffalo to the win — the Bills have had four different head coaches and five different starting quarterbacks.

But if there’s any truth to the idea of “any given Sunday” in the NFL, you would think Buffalo would have broken through at least once since 2003. And while there have been close ones — three of the losses have been by a combined 10 points, and in last year’s regular-season opener, the Patriots needed a fourth-quarter comeback to beat the Bills 25-24 — Buffalo has failed to break through.

“We’re ready to beat New England and I know coach wants to go up there and beat New England,” Whitner said. “So we have an opportunity and what we do with that opportunity is up to us.”

On paper, there’s little evidence to suggest the Bills will be able to turn things around on Sunday. They have managed just 19 points in two losses, and have decided to switch up quarterbacks, going from Trent Edwards to Ryan Fitzpatrick.

But even with the departure of special teams coach Bobby April, they remain one of the better special teams units in the league. And their “three-headed monster” of Marshawn Lynch, C.J. Spiller and Fred Jackson in the backfield (a phrase used by New England linebacker Tully Banta-Cain) does make them dangerous on the ground.

“You can’t go to sleep with them,” wide receiver Wes Welker said of Buffalo. “You have to play every single play and make sure that you’re staying on top of everything.”

That means that when it comes to the Bills, any laughter from the home team will be saved for Sunday afternoon around 4:30.

“This is the National Football League. It’s early. I always expect the best out of a team we’re playing. Teams normally play the best when they play us, too. So, it’s any given Sunday,” said nose tackle Vince Wilfork. “But we know what we need to do. This week is about how well we can play. It’s the Patriots. Can we get better? It’s about what we can do in putting it on the field Sunday.”