The Celtics dropped a 106-77 decision at Los Angeles' Staples Center on Thursday night.
The win was the Clippers' 15th in a row, making them the first team to win that many consecutive game since the Celts' 19-game win streak in the 2008-09 season.
The Celtics never led, committing 18 turnovers in the process. Kevin Garnett scored 16 points for the visitors, who dropped to 14-14 with their fifth loss in the last seven games. Paul Pierce and Jeff Green each added 12 points.
It marked the Clippers' largest-ever win over the Celtics, who were held to just 10 points over the final 12 minutes.
The Clippers, who saw their reserves score as many points as their starters (53 points), got 21 points from sub Matt Barnes and 17 out of Jamal Crawford, another reserve.
The closest the Celtics would come after the first few minutes was when back-to-back 3-pointers by Jason Terry and Courtney Lee cut the Clippers' lead to four points early in the second quarter. Los Angeles would, however, manage to extend its advantage to 60-47 at halftime.