Vladimir Guerrero's one-out, two-run single to center broke a 4-4 tie in the eighth and led the Orioles to a stunning 6-4 win over the Red Sox Wednesday night in the Fenway regular-season home finale. The Red Sox had built a 4-1 lead thanks to a single, double and triple from Carl Crawford only to have the Orioles come back with two in the seventh and two in the eighth against starter and loser Josh Beckett. 

A day after throwing a 32-pitch simulated game, Clay Buchholz said he was "sore from the first bullpen in spring training kind of sore," but was ready to executed another throwing session to Red Sox hitters either Thursday or Friday.

Making his weekly appearance on the Big Show, Terry Francona told Glenn Ordway and Michael Holley that he wasn't sure who will start for the Red Sox vs. the Yankees in the series finale at Yankee Stadium on Sunday. Francona had indicated earlier in the week that Eric Bedard might start in place of John Lackey, but on Wednesday Francona indicated that Bedard's 76-pitch performance on Tuesday (his first start since September 3) will take the left-hander out of the conversation for Sunday.

Dustin Pedroia will bat fifth in the lineup for the first time in his career Wednesday as the struggling Red Sox look to Josh Beckett (13-5, 2.50) as they hope to knock off Tommy Hunter (3-3, 5.31) and the Orioles and end a 10-game homestand on a high note. The Sox have lost six of their first nine on the homestand, including Tuesday's 7-5 loss to Baltimore. This will be the final regular-season home game for the Sox, as they travel to New York (three games) and Baltimore (four games) to close out the season.

Lineup:

Ellsbury, 8

Aviles, 5

Gonzalez, 3

Terry Francona made his weekly appearance on The Big Show on Wednesday. The Sox manager was asked about Clay Buchholz, who threw a 32-pitch simulated game at Fenway Park on Tuesday. Buchholz has been on the disabled list since June 16 with a stress fracture in his back.

"He's a little sore, not sore in his back, but sore on his side, which we all thought," Francona said. "He's extending a little more than he has in the past. He will do this again either tomorrow or Friday, we're trying to figure out what is in his best interest."

Former Red Sox general manager Dan Duquette joined the Dennis & Callahan show Wednesday morning to talk about the Red Sox' September collapse.

"It's pretty clear," Duquette said. "The Sox are still leading the league in runs scored. Their pitching's just totally collapsed here in September. Some of it's injuries. You know what happens when you have a few injuries and you don't have the guys behind there to come in and do the job. And it's hard to do it with any pitching staff, but when you're in a pennant race, things just start to snowball a little bit.

Left-hander Erik Bedard continued a month of poor results by the Red Sox rotation. (AP)What is the current state of the Red Sox rotation?



Jonathan Papelbon reflects on his second blown save of the season. (AP)He was all that was left.



ROB BRADFORD

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Dustin Pedroia has been one of the outspoken leaders in the Red Sox clubhouse during the team's September swoon that has opened the door for the Rays to make a run at the wild card position Boston currently holds. After Tuesday's excruciating 7-5 loss to the Orioles, Pedroia told the group of reporters around his locker that his teammates aren't lacking for confidence.

A stand-up Jonathan Papelbon took full responsibility for his first blown save in 26 chances Tuesday night as the Red Sox watched a 5-4 lead in the eighth disappear when he allowed a two-out bases-clearing double to Robert Andino, leading to a 7-5 loss to the Orioles at Fenway Park.