The Patriots announced Wednesday nigh that four players — offensive lineman Stephen Neal, defensive lineman Myron Pryor, cornerback Jonathan Wilhite and defensive lineman Mike Wright — have been downgraded to out for Thursday's game in Detroit against the Lions. All four players have struggled with injury over the last week, with Wright sustaining a concussion last week against the Colts, while Neal (shoulder), Pryor (back) and Wilhite (hip) have all had injury issues over the last week or two.

For the first time this season, quarterback Tom Brady is officially listed as "questionable" entering a game. Brady is one of six Patriots listed as questionable. Brady has been dealing with a sore foot since the Browns game on Nov. 7 and has been limited in practice since. Here's the complete injury report for Wednesday, with practice participation only an estimate as the team held only a walk-through on Monday and Wednesday before departing for Detroit and its Thursday game against the Lions. 

Did Not Participate

Peter King of Sports Illustrated and NBC Sports made his weekly appearance on the Dale & Holley show Wednesday morning and talked about the Patriots' Thanksgiving Day matchup against the Lions in Detroit.

 

ESPN's Trent Dilfer was a guest of the Dennis & Callahan show Wednesday morning, and the former NFL quarterback discussed a variety of topics and offered his analysis of the Patriots.

 

ESPN's Adam Schefter checked in for his weekly appearance on the Dennis & Callahan show Wednesday morning to talk about news from around the NFL.

 

Asked which of the three Thanksgiving Day games is most likely to provide an upset, Schefter pointed to the Patriots-Lions matchup. "I think that New England is going to have a tough game," he said. "That's not going to be an easy matchup. If you watch the Lions this year, they play everybody — everybody — tough, and they always find a way to screw it up. Always."

Here are 10 things worth keeping an eye on in Thursday’s Patriots-Lions game:

WHEN THE PATRIOTS HAVE THE FOOTBALL



Mailbag Time, and I'm fairly certain this is the only place on WEEI.com where you'll find both a Manning vs. Brady QB debate AND a Jamie Lee Curtis vs. Denise Richards cleavage debate.



KIRK MINIHANE

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FOXBORO -- While the most-recent classic between the Patriots and Colts on Sunday at Gillette Stadium was a nail-biter of a win on the field, the game was a blowout victory in the ratings.

 

The Patriots 31-28 win over the Colts on Sunday drew the third-highest regular season local ratings in franchise history with a 42.04 household rating in the Boston market. Over one million people tuned in to WBZ-TV for the latest installment of Brady vs. Manning.

 

When it comes to the injury report, the Lions added two players to the "Did Not Participate" group on Tuesday, with defensive ends Kyle Vanden Bosch (knee) and Lawrence Jackson (concussion) both sidelined. They did, however, move running back Jahvid Best from "Did Not Participate" to "Limited Participation." Here's the complete injury report:

Did Not Participate
K Jason Hanson (right knee)
DE Lawrence Jackson (concussion)
TE Tony Scheffler (ribs)
QB Matthew Stafford (right shoulder)

FOXBORO — Quarterback Tom Brady was one of four Patriots players who did not participate in practice today — he was listed on the Tuesday injury report with "right shoulder/foot," which left him limited on Monday. Here's the complete injury report:

Did Not Participate
QB Tom Brady (right shoulder/foot)
G Stephen Neal (shoulder)
CB Jonathan Wilhite (hip)
DL Mike Wright (neck/concussion)

Limited Participation
S Jarrad Page (calf)
NT Myron Pryor (back)